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Combine garlic powder, onion powder, smoked paprika, brown sugar, kosher salt, black pepper, and chili powder in a small bowl.
Whisk thoroughly until all spices and sugar are evenly distributed and no clumps remain.
Transfer the seasoning blend to an airtight container (jar or spice shaker).
Store in a cool, dark place for up to 6 months.
Use as desired: rub onto chicken, pork, or beef before grilling or baking, or sprinkle over roasted potatoes and vegetables.